01
Front
How do UFH and LMWHs reduce clot formation?
Back
Both enhance antithrombin’s inhibition of activated clotting factors, reducing clot formation.
Free Online Flashcard Deck
1 Heparin and Low-Molecular-Weight Heparins Free Online FlashCards
Study 1 Heparin and Low-Molecular-Weight Heparins with 12 free online flashcards. Review key terms, definitions, and concepts with this interactive flashcard deck.
12 cards
02
Front
When may UFH be preferred because of its controllability?
Back
UFH may be preferred when rapid adjustment or stopping of anticoagulation is important.
03
Front
What are common preventive and treatment uses of heparins?
Back
They may prevent venous thromboembolism in at-risk hospitalized or postoperative patients, or treat deep-vein thrombosis and pulmonary embolism.
04
Front
What should be checked before giving an LMWH dose?
Back
Check the indication, prescribed regimen, relevant body weight, kidney function, bleeding risk, and the correct product and concentration.
05
Front
What commonly guides adjustment of a therapeutic UFH infusion?
Back
A therapeutic UFH infusion is commonly adjusted using the aPTT or an institution’s validated anti-Xa protocol.
06
Front
What complication should be considered after a platelet fall and new thrombosis during heparin therapy?
Back
Consider heparin-induced thrombocytopenia (HIT), an immune-mediated reaction that can cause thrombosis despite a low platelet count.
07
Front
What are two important hazards of heparin therapy?
Back
Bleeding and thrombocytopenia, including HIT, are important hazards of heparin therapy.
08
Front
How does protamine reversal differ for UFH and enoxaparin?
Back
Protamine sulfate reverses UFH more completely; reversal of enoxaparin-associated anticoagulation is incomplete.
09
Front
Which clotting factors does UFH substantially inhibit?
Back
UFH substantially inhibits both thrombin (factor IIa) and factor Xa.
10
Front
How does LMWH activity compare across anti-Xa and anti-IIa effects?
Back
LMWHs have proportionally greater anti-Xa than anti-IIa activity.
11
Front
Why might severe renal impairment favor UFH over LMWH?
Back
UFH may be preferred because severe renal impairment can make LMWH accumulation a concern.
12
Front
Why are prophylactic and treatment LMWH doses not interchangeable?
Back
Prophylactic and treatment regimens differ: treatment is commonly weight-based, while prophylaxis is often fixed-dose.
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