What are typical adult pH, PaCO₂, and HCO₃⁻ ranges?
Typical adult ranges are pH , PaCO₂ mm Hg, and HCO₃⁻ mEq/L.
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What are typical adult pH, PaCO₂, and HCO₃⁻ ranges?
Typical adult ranges are pH 7.35–7.45, PaCO₂ 35–45 mm Hg, and HCO₃⁻ 22–26 mEq/L.
What do low and high arterial pH indicate?
A pH below 7.35 indicates acidemia; a pH above 7.45 indicates alkalemia.
Which ABG values represent the respiratory and metabolic components?
PaCO₂ is the respiratory component; HCO₃⁻ is the metabolic component.
How do PaCO₂ and HCO₃⁻ changes affect pH?
PaCO₂ moves pH in the opposite direction, while HCO₃⁻ moves pH in the same direction.
What does compensation do in an acid–base disorder?
Compensation changes the other component in a direction that brings pH toward normal. It does not prove the primary disorder has resolved.
Does a near-normal pH always mean acid–base status is normal?
No. Abnormal PaCO₂ and HCO₃⁻ with a near-normal pH may reflect compensation or two opposing disorders.
What is Winter’s formula used to estimate?
For metabolic acidosis, expected PaCO₂ is 1.5×HCO₃⁻+8, with a margin of ±2 mm Hg.
When should a mixed acid–base disorder be considered?
Consider a mixed disorder when compensation falls outside the expected range or both PaCO₂ and HCO₃⁻ push pH in the same abnormal direction.
How does HCO₃⁻ typically change in acute respiratory acidosis?
In acute respiratory acidosis, HCO₃⁻ rises by about 1 mEq/L per 10 mm Hg increase in PaCO₂.
With HCO₃⁻ 12 mEq/L, is PaCO₂ 27 mm Hg appropriate compensation?
Expected PaCO₂ is 26±2 mm Hg. A measured PaCO₂ of 27 mm Hg is within that range, indicating appropriate respiratory compensation.
What disorder is indicated when low HCO₃⁻ and high PaCO₂ both lower pH?
It is mixed metabolic and respiratory acidosis: low HCO₃⁻ and elevated PaCO₂ both push pH downward.
How does HCO₃⁻ typically change in chronic respiratory acidosis?
In chronic respiratory acidosis, HCO₃⁻ rises by about 3.5–4 mEq/L per 10 mm Hg increase in PaCO₂.
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