5 Therapeutic Monitoring of Anti-Infective Medications Free Online FlashCards

When should a gentamicin trough be collected?

Collect a gentamicin trough immediately before the next dose.

What should be reviewed with a gentamicin trough?

Review the level alongside renal function and the exact dose and sample times; follow the applicable protocol before adjusting therapy.

Why does worsening renal function matter during gentamicin therapy?

Changing or impaired renal clearance can cause aminoglycoside accumulation, so reassess levels and dosing in clinical context.

Is a vancomycin trough target of 15–20 mg/L still recommended for serious MRSA infection?

Trough-only targeting at 15–20 mg/L is no longer recommended for serious MRSA infections.

How is fluconazole dosing generally approached in renal impairment?

For multiple-dose therapy, give the usual loading dose, then consider adjusting maintenance dosing for renal function and the clinical indication.

What fluconazole regimen is noted as an exception to renal maintenance-dose adjustment?

A single-dose vaginal candidiasis regimen is an exception to the usual maintenance-dose adjustment approach.

Which laboratory measures are important during amphotericin B therapy?

Monitor renal function, potassium, magnesium, liver function, and blood counts.

Which renal and electrolyte problems can occur with amphotericin B?

Amphotericin B can impair renal function and cause low potassium and magnesium.

What should be checked first when a voriconazole trough is unexpectedly low?

Confirm sample timing and review adherence, administration, interacting medicines, and relevant clinical changes before changing the dose.

Which organ function should be monitored during voriconazole therapy?

Monitor liver function during voriconazole therapy.

What should be reassessed if renal function worsens during high-dose IV acyclovir?

Promptly reassess the dose and interval using current renal function; acyclovir is substantially eliminated unchanged by the kidneys.

What supportive measure helps reduce renal risk with high-dose IV acyclovir?

Adequate hydration is important to help reduce renal risk during high-dose IV acyclovir therapy.