Study 6 Adverse Effects and Safety with 12 free online flashcards. Review key terms, definitions, and concepts with this interactive flashcard deck.
What can tinnitus, dizziness, and rising creatinine signal during gentamicin treatment?
Tinnitus, dizziness, and rising creatinine may signal aminoglycoside ototoxicity and nephrotoxicity; promptly notify the prescriber for reassessment.
What should a patient do about sudden Achilles tendon pain while taking ciprofloxacin?
Tendon pain or swelling may be a serious fluoroquinolone adverse effect. Stop the medication and promptly contact the prescriber for advice about an alternative.
Which medication class makes tendon injury risk especially important with fluoroquinolones?
Corticosteroid use is an important risk factor to consider when assessing fluoroquinolone-associated tendon injury.
What monitoring is needed when metronidazole is used with warfarin?
Metronidazole can increase warfarin’s anticoagulant effect, so prothrombin time/INR should be carefully monitored as directed.
What should patients avoid during metronidazole treatment and for three days afterward?
Avoid alcohol and products containing propylene glycol during metronidazole treatment and for at least three days afterward.
What increases the risk of kidney injury from intravenous acyclovir?
Intravenous acyclovir can injure the kidneys, especially with dehydration, existing renal impairment, or other nephrotoxic medicines. Hydration and renal monitoring help reduce risk.
What anticoagulation concern arises when fluconazole is taken with warfarin?
Fluconazole can increase prothrombin time in patients taking warfarin, so the care team should review the combination and arrange appropriate monitoring.
Why does fluconazole require caution with amiodarone?
Fluconazole can amplify QT-prolonging effects of medicines such as amiodarone; the care team should review the combination and determine appropriate monitoring.
What test is essential before starting primaquine?
Obtain a quantitative G6PD activity test before starting primaquine because G6PD deficiency increases the risk of hemolytic anemia.
What patient-specific precaution should be considered before primaquine treatment besides G6PD status?
Pregnancy is an important precaution to consider before starting primaquine.
Which laboratory changes should be monitored with amphotericin B?
Amphotericin B can impair renal function and lower potassium and magnesium; monitor renal function and electrolytes.
Why is low potassium during amphotericin B treatment concerning for a patient taking digoxin?
Amphotericin-related low potassium can increase digoxin toxicity and cardiac risk, so electrolytes and cardiac status need monitoring.