01
True or false
1 point
True or false: An intravenous drug enters systemic circulation directly, so it does not need to be absorbed from the gastrointestinal tract and has complete systemic bioavailability.
Free Practice Quiz Question List
1 Foundations of Pharmacology Online Quiz Questions
Use this free practice quiz with 20 questions to review 1 Foundations of Pharmacology, test your knowledge, and prepare for your next test or exam.
20 questions
02
Choose one
1 point
A medicine is classified as both an antihypertensive and an ACE inhibitor. Which interpretation correctly distinguishes these classifications?
- A
Both terms describe how the drug works.
- B
Antihypertensive describes therapeutic use, and ACE inhibitor describes pharmacologic action.
- C
Antihypertensive describes regulatory status, and ACE inhibitor describes chemical structure.
- D
Both terms describe regulatory status.
03
Fill in the blank
1 point
In ADME, the chemical alteration of a drug, often by liver enzymes, is called .
04
Choose all
1 point
Select all the factors listed that can directly contribute to differences in how people respond to a medicine.
- A
Kidney function
- B
Inherited differences in drug-metabolizing enzymes
- C
Whether the medicine is prescription or over-the-counter
- D
Interactions with other medicines
05
Written response
1 point
What term describes the time required for a drug's concentration in the body to fall by about half under the relevant elimination conditions?
06
Choose one
1 point
An oral drug is partly broken down in the gut or liver before reaching systemic circulation. What is this called?
- A
Distribution into tissues
- B
Excretion through the kidneys
- C
First-pass effect
- D
Steady state
07
Fill in the blank
1 point
A drug that binds to and activates a receptor is an . A drug that binds to and blocks receptor activation by another substance is an .
08
True or false
1 point
True or false: A drug that is more potent necessarily provides greater clinical benefit than a less potent drug.
- A
True
- B
False
09
Choose all
1 point
Select all the factors listed that can affect a drug's distribution between blood and tissues.
- A
Blood flow
- B
Tissue permeability
- C
Protein binding
- D
Regulatory status as prescription or over-the-counter
- E
Body composition
10
Written response
1 point
A dose of 80 mg results in 60 mg reaching systemic circulation as active drug. What is the bioavailability, expressed as a percentage? Enter the number of percentage points; for example, an answer of 25 means 25%.
11
Choose one
1 point
Which description best defines a drug's therapeutic window?
- A
The concentration at which a drug first begins to be excreted
- B
The range between concentrations likely to be effective and those likely to cause toxicity
- C
The dose required to produce a specified effect
- D
The maximum response a drug can produce
12
Open ended
1 point
A person taking a drug that is normally cleared by the kidneys develops reduced kidney function. Explain how this could affect the drug's presence in the body and what may need to happen to the prescribed regimen.
13
Choose one
1 point
Which statement about FDA-approved generic medicines is supported by the material?
- A
They must have the same chemical structure as every other medicine in their therapeutic class.
- B
They are necessarily available over the counter.
- C
They are required to provide the same clinical benefit and risks as their brand-name counterparts.
- D
They must work through the same mechanism as all medicines used for the same condition.
14
Choose one
1 point
Lisinopril is used to lower blood pressure and inhibits angiotensin-converting enzyme. Which classification identifies how the drug works?
- A
Its therapeutic class is ACE inhibitor, which describes its mechanism.
- B
Its pharmacologic class is ACE inhibitor, which describes how it works.
- C
Its regulatory status is ACE inhibitor, which describes how it is supplied.
- D
Its chemical structure class is antihypertensive, which describes its mechanism.
15
Choose one
1 point
A medicine is administered intravenously. Which statement best describes its entry into systemic circulation?
- A
It must undergo first-pass metabolism before entering systemic circulation.
- B
It requires gastrointestinal absorption to become systemically available.
- C
It enters systemic circulation directly and has complete systemic bioavailability.
- D
Its bioavailability is necessarily lower than that of an oral dose.
16
Choose one
1 point
A drug circulates in both protein-bound and unbound forms. Which statement best explains how these forms relate to the drug's availability to interact with targets?
- A
The unbound portion is generally available to leave the bloodstream and interact with targets.
- B
The protein-bound portion is always inactive and cannot later become available.
- C
Protein binding guarantees that the entire dose reaches the target tissue.
- D
Only protein-bound drug can leave the bloodstream and interact with targets.
17
True or false
1 point
True or false: A more potent drug necessarily produces a greater maximum clinical effect than a less potent drug.
- A
True
- B
False
18
Choose one
1 point
A medicine is given as an inactive prodrug and becomes active after chemical alteration in the body. Which process explains this change?
- A
A prodrug is already active, and metabolism always reduces its activity.
- B
Metabolism can activate a prodrug by converting it into an active form.
- C
Metabolism refers only to the removal of a drug through the kidneys.
- D
A prodrug bypasses chemical alteration before producing its effect.
19
Written response
1 point
A medication is given repeatedly. Over time, its rate of administration balances its rate of elimination. What is this condition called?
20
Written response
1 point
A patient takes a medication as directed, but its effect becomes weaker after repeated exposure. What term describes this reduced response?