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Free Practice Quiz Question List

3 Metabolism and Excretion Online Quiz Questions

Use this free practice quiz with 20 questions to review 3 Metabolism and Excretion, test your knowledge, and prepare for your next test or exam.

20 questions
01
Written response
1 point

What term describes the chemical alteration of a drug by the body?

02
True or false
1 point

Drug metabolism occurs only in the liver.

  1. A

    True

  2. B

    False

03
Choose all
1 point

Which routes can contribute to drug excretion? Select all correct choices.

  1. A

    Kidneys, with substances entering urine

  2. B

    Skin, as the major route for most medicines

  3. C

    Bile and feces

  4. D

    Lungs, for volatile substances

04
Fill in the blank
1 point

With first-order kinetics, a of the amount present is removed during each equal time interval.

05
True or false
1 point

Every drug must be metabolized before it can be excreted.

  1. A

    True

  2. B

    False

06
Choose one
1 point

A drug's active effect comes from its parent compound. If another drug inhibits the enzymes that metabolize it, what is a potential result?

  1. A

    Metabolism speeds up, so exposure must decrease

  2. B

    The drug is converted into a prodrug

  3. C

    Metabolism slows, potentially increasing drug exposure

  4. D

    Excretion stops completely

07
Choose all
1 point

Which outcomes can result from drug metabolism? Select all correct choices.

  1. A

    Inactivate a drug

  2. B

    Produce an active metabolite

  3. C

    Always make a drug inactive

  4. D

    Activate a prodrug that was initially inactive

08
Fill in the blank
1 point

When elimination pathways are saturated, zero-order elimination removes a roughly per unit time.

09
Open ended
1 point

A patient has declining kidney function and takes a drug eliminated mainly by the kidneys. Explain how the drug's clearance and half-life may change, and what this could mean for dosing decisions.

10
Written response
1 point

What renal process returns a substance from the kidney tubules to the blood?

11
Choose one
1 point

A drug leaves the body in feces after being eliminated into bile, without first being chemically changed. Which process describes its removal from the body?

  1. A

    Metabolism

  2. B

    Excretion

  3. C

    Enzyme induction

  4. D

    Reabsorption

12
True or false
1 point

For a drug following first-order elimination, a constant fraction is removed during equal time intervals, even as the amount of drug remaining decreases.

  1. A

    True

  2. B

    False

13
Choose one
1 point

An active drug is normally inactivated by liver enzymes. A second drug inhibits those enzymes. Which outcome is a reasonable possibility?

  1. A

    Metabolism speeds up, so exposure is likely to fall.

  2. B

    Metabolism slows down, so exposure may rise.

  3. C

    Metabolism is unchanged, so exposure must fall.

  4. D

    The drug becomes a prodrug, so its active effects must fall.

14
Choose one
1 point

A medicine depends on the liver for its clearance. If liver function is reduced, which change may occur?

  1. A

    Clearance must increase because less drug reaches the liver.

  2. B

    Clearance may decrease because the drug depends on liver function.

  3. C

    Clearance is unaffected by liver function for every drug.

  4. D

    The drug must be excreted unchanged by the kidneys.

15
Choose one
1 point

A drug is eliminated largely unchanged in urine. A patient's kidney function declines. What may happen to the drug's renal clearance?

  1. A

    Its renal clearance will necessarily increase.

  2. B

    Its renal clearance may decrease.

  3. C

    Its metabolism must speed up to compensate.

  4. D

    Its route of elimination will necessarily change to the lungs.

16
Written response
1 point

A drug is eliminated at 72 mg/h72\ \text{mg/h} while its plasma concentration is 4 mg/L4\ \text{mg/L}. Using CL=elimination rateplasma concentration\text{CL} = \frac{\text{elimination rate}}{\text{plasma concentration}}, calculate its clearance in L/h.

17
Choose one
1 point

A medicine is an inactive prodrug that becomes active through metabolism. If an enzyme-inducing interaction speeds that metabolism, what may happen?

  1. A

    Its active effects must decrease because metabolism is faster.

  2. B

    Its metabolism must slow because enzymes are induced.

  3. C

    Its active effects may increase because metabolism can activate it.

  4. D

    It must be excreted unchanged.

18
Choose one
1 point

In the simplified one-compartment, first-order model, t1/2=0.693×Vd÷CLt_{1/2} = 0.693 \times Vd \div CL. If VdVd doubles while clearance stays constant, what happens to the half-life?

  1. A

    The half-life is cut in half.

  2. B

    The half-life doubles.

  3. C

    The half-life stays the same.

  4. D

    The half-life becomes zero.

19
Choose one
1 point

A drug's elimination pathways are saturated over a particular concentration range. Which pattern is expected over that range?

  1. A

    A constant fraction is removed per unit time at all concentrations.

  2. B

    The half-life is fixed across all concentrations.

  3. C

    A roughly constant amount is removed per unit time over the saturated range.

  4. D

    The drug cannot be eliminated.

20
Written response
1 point

Age-related changes can affect drug clearance, but their effects are not the same in every case. What two factors does the material say the effect varies by?