Free Practice Quiz Question List

2 Absorption and Distribution Online Quiz Questions

Use this free practice quiz with 20 questions to review 2 Absorption and Distribution, test your knowledge, and prepare for your next test or exam.

20 questions

True or false

1 point

True or false: Absorption moves a drug from its administration site into systemic circulation, whereas distribution is the reversible movement of the drug between blood and body tissues.

A
True
B
False

Choose one

1 point

Which statement best distinguishes topical from transdermal drug formulations?

A
Both are designed to produce only local effects in the skin.
B
Topical drugs are often used for local effects, while transdermal formulations are designed to enter systemic circulation.
C
Transdermal formulations enter systemic circulation without crossing the skin.
D
Topical drugs must enter systemic circulation, while transdermal drugs remain on the skin surface.

Fill in the blank

1 point

Drug absorbed from the gut may be metabolized in the intestinal wall or liver before reaching systemic circulation. This is called the .

True or false

1 point

True or false: The apparent volume of distribution is a calculated measure and does not necessarily correspond to an actual anatomical volume.

A
True
B
False

Choose one

1 point

Why is the bioavailability of an intravenously administered drug considered to be 1 (100%)?

A
The drug is absorbed completely from the gastrointestinal tract.
B
The drug avoids all metabolism after entering the body.
C
The drug is delivered directly into systemic circulation.
D
The drug distributes evenly to all body tissues.

Choose all

1 point

Which factors can affect how readily a drug becomes available for absorption? Select all that apply.

A
The drug's solubility
B
The drug's particle size
C
The formulation, such as immediate-release versus extended-release
D
The drug's ability to cross membranes
E
The extent of the drug's binding to tissues after it enters systemic circulation

Written response

1 point

What pharmacokinetic process can reduce the amount of unchanged drug reaching systemic circulation when a gut-absorbed drug is metabolized in the intestinal wall or liver first?

Fill in the blank

1 point

Compared with a poorly perfused tissue, a well-perfused tissue generally receives a drug after it enters systemic circulation.

Choose one

1 point

A drug binds extensively and reversibly to plasma proteins. What is the most direct implication for its movement from blood into tissues?

A
Protein-bound drug is permanently prevented from leaving the bloodstream.
B
Protein binding can leave less drug immediately available to move from blood into tissues.
C
Protein binding guarantees that all drug accumulates in fatty tissue.
D
Protein binding increases the fraction of drug that is free in plasma.

Choose all

1 point

Which factors can influence how a drug distributes among tissues after entering systemic circulation? Select all that apply.

A
The blood flow to tissues
B
Membrane permeability and properties such as molecular size and ionization
C
Body composition and physiological conditions
D
How quickly a tablet dissolves in the gastrointestinal tract

Written response

1 point

A non-IV dose produces half the dose-normalized AUC of an IV dose of the same drug. What is the approximate absolute bioavailability as a decimal?

Choose one

1 point

Which route is designed to absorb a drug through tissue under the tongue and can avoid much of the gastrointestinal absorption process and hepatic first pass?

A
Oral administration, because the drug is swallowed
B
Sublingual administration, because the drug is absorbed through tissue under the tongue
C
Intramuscular administration, because the drug is injected into muscle
D
Topical administration, because the drug is applied to the skin for a local effect

Open ended

1 point

Two formulations of the same drug ultimately deliver the same fraction of the administered dose to systemic circulation as unchanged drug, but one produces a faster rise in plasma concentration. Explain how both observations can be true.

Choose one

1 point

A drug is administered intravenously. Which statement best explains what happens to its absorption as a pharmacokinetic step?

A
It bypasses both absorption and distribution.
B
It enters systemic circulation directly, bypassing absorption.
C
It must be absorbed through the gastrointestinal tract.
D
It cannot move from blood into tissues.

True or false

1 point

True or false: A transdermal formulation is designed to cross the skin and enter systemic circulation.

A
True
B
False

Written response

1 point

What pharmacokinetic term names the fraction of an administered dose that reaches systemic circulation as unchanged drug?

Choose one

1 point

A patient needs a route that can avoid much of gastrointestinal absorption and hepatic first-pass metabolism. Which route best fits this goal?

A
The drug is absorbed mainly from the gastrointestinal tract and passes through the liver before reaching systemic circulation.
B
The drug enters systemic circulation directly from an injection.
C
The drug is absorbed through tissues under the tongue or in the cheek, potentially avoiding much of hepatic first pass.
D
The drug crosses the skin from a formulation designed for systemic delivery.

Choose one

1 point

After a drug enters systemic circulation, which tissue would generally receive it sooner: a well-perfused tissue or a poorly perfused tissue?

A
The well-perfused tissue, because it receives greater blood flow.
B
The poorly perfused tissue, because lower blood flow increases delivery speed.
C
Both tissues must receive drug at the same time.
D
Neither tissue receives drug until the drug is bound to tissue proteins.

Choose one

1 point

A drug is extensively bound to plasma proteins. What is the most likely immediate effect on its movement from blood into tissues?

A
Protein-bound drug is always more able to leave the bloodstream than free drug.
B
Protein binding can reduce the amount of drug immediately available to move from blood into tissues.
C
Protein binding prevents any reversible movement between blood and tissues.
D
The free fraction generally remains permanently in the bloodstream.

Written response

1 point

A non-IV dose produces half the dose-normalized AUC of the same drug given intravenously. What is the approximate absolute bioavailability in percent?