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4 DNA Structure and Replication Online Quiz Questions

Use this free practice quiz with 20 questions to review 4 DNA Structure and Replication, test your knowledge, and prepare for your next test or exam.

20 questions
01
True or false
1 point

In semiconservative DNA replication, each daughter double helix contains one original strand and one newly synthesized strand.

  1. A

    True

  2. B

    False

02
Written response
1 point

A nucleosome core contains about how many base pairs of DNA? Enter the stated approximate value.

03
Choose one
1 point

A DNA strand has the sequence 5′-A G C T-3′. Which option gives its complementary strand written in the 3′ to 5′ direction?

  1. A

    3′-A G C T-5′

  2. B

    3′-T C G A-5′

  3. C

    5′-T C G A-3′

  4. D

    3′-T G C A-5′

04
Fill in the blank
1 point

Primase makes an RNA that provides a starting strand for DNA polymerase.

05
Choose one
1 point

Which statement best describes where bacterial DNA is organized?

  1. A

    A bacterial cell has its DNA in a nucleoid rather than a membrane-bound nucleus.

  2. B

    A bacterial cell packages its DNA into nucleosomes inside a nucleus.

  3. C

    A bacterial cell typically stores all its DNA in multiple linear chromosomes inside a nucleus.

  4. D

    A bacterial cell has no DNA-binding proteins or other means of compacting its genome.

06
Choose all
1 point

Select all statements that correctly describe how proteins help open and stabilize DNA at a replication fork.

  1. A

    Helicase separates paired DNA strands.

  2. B

    Single-strand DNA-binding proteins help keep exposed strands from re-pairing.

  3. C

    Topoisomerases relieve twisting strain ahead of the replication fork.

  4. D

    DNA ligase unwinds the double helix by separating paired bases.

  5. E

    Primase seals breaks between newly synthesized DNA fragments.

07
True or false
1 point

In eukaryotic cells, licensing replication origins before DNA synthesis and activating them during S phase helps ensure each genome region is replicated once per cell cycle.

  1. A

    True

  2. B

    False

08
Written response
1 point

What is the term for a smaller DNA molecule that a bacterial or archaeal cell may carry in addition to its main chromosome?

09
Fill in the blank
1 point

DNA polymerases extend a newly synthesized DNA strand only in the direction.

10
Choose all
1 point

Select all statements supported by the organization of eukaryotic DNA.

  1. A

    Eukaryotic DNA is divided among multiple, usually linear chromosomes in the nucleus.

  2. B

    DNA wraps around histone proteins to form nucleosomes.

  3. C

    Chromatin structure is dynamic and helps organize access to DNA.

  4. D

    Eukaryotic DNA is organized in a nucleoid instead of a nucleus.

  5. E

    Chromatin is always a permanently condensed fiber.

11
Written response
1 point

What term means an organism’s complete set of genetic material, including both genes and DNA sequences that do not encode proteins?

12
Choose one
1 point

At the end of a linear eukaryotic chromosome, which action can help maintain the telomere when the final lagging-strand RNA primer cannot be replaced in the usual way?

  1. A

    It removes all RNA primers from the lagging strand.

  2. B

    It seals breaks between Okazaki fragments.

  3. C

    It can extend telomeric DNA in certain cells.

  4. D

    It separates paired DNA strands at each replication fork.

13
Choose one
1 point

What is the role of a sliding clamp during DNA replication?

  1. A

    It removes wrongly paired nucleotides during proofreading.

  2. B

    It helps hold DNA polymerase on the template.

  3. C

    It makes RNA primers.

  4. D

    It relieves twisting strain ahead of the replication fork.

14
Open ended
1 point

Compare how the leading and lagging strands are synthesized at a replication fork. Include their direction relative to fork movement, how the lagging strand is started in pieces, and how those pieces are joined into a continuous strand.

15
Choose one
1 point

As a replication fork advances, twisting strain builds up in the DNA ahead of it. Which enzyme relieves this strain by temporarily cutting and rejoining DNA?

  1. A

    Topoisomerase

  2. B

    Helicase

  3. C

    Primase

  4. D

    DNA ligase

16
Choose one
1 point

A DNA template strand is 3′-A G C T-5′. Which sequence and orientation describe its complementary strand?

  1. A

    5′-A G C T-3′

  2. B

    5′-T C G A-3′

  3. C

    3′-T C G A-5′

  4. D

    5′-A C G T-3′

17
Choose one
1 point

A DNA polymerase is positioned at an exposed template but has no starting strand to extend. What must be supplied before it can begin synthesizing DNA?

  1. A

    Helicase must first join the incoming nucleotides together.

  2. B

    DNA ligase must first create a continuous template strand.

  3. C

    A primer must provide a starting strand for DNA polymerase to extend.

  4. D

    A sliding clamp must synthesize the first stretch of DNA.

18
Choose one
1 point

After one round of DNA replication, how are the original and newly synthesized strands arranged in the two daughter double helices?

  1. A

    One daughter helix contains both original strands, and the other contains two new strands.

  2. B

    Each daughter helix contains one original strand and one newly synthesized strand.

  3. C

    Each daughter helix contains two newly synthesized strands, while the original strands are discarded.

  4. D

    Each daughter helix contains sections of original and new DNA mixed within both strands.

19
True or false
1 point

True or false: DNA polymerase can extend a newly synthesized DNA strand in the 3′ to 5′ direction.

  1. A

    True

  2. B

    False

20
Written response
1 point

As helicase unwinds DNA, which enzyme class relieves the twisting strain that builds ahead of the replication fork?