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Free Practice Quiz Question List

5 Genomics and Genome Analysis Online Quiz Questions

Use this free practice quiz with 20 questions to review 5 Genomics and Genome Analysis, test your knowledge, and prepare for your next test or exam.

20 questions
01
True or false
1 point

True or false: A higher N50 by itself shows that a genome assembly is more accurate and complete.

  1. A

    True

  2. B

    False

02
Choose one
1 point

Which statement best describes the relationship between genome size and an organism’s biological complexity?

  1. A

    A larger genome always belongs to a biologically more complex organism.

  2. B

    Genome size does not directly indicate an organism’s biological complexity.

  3. C

    Only eukaryotes have genomes that vary in size.

  4. D

    Genome size is determined only by the number of protein-coding genes.

03
Fill in the blank
1 point

Genome annotation has two complementary tasks. The task that locates genomic features and defines their boundaries is annotation; the task that assigns likely roles to those features is annotation.

04
Written response
1 point

What is the term for a smaller DNA molecule that may accompany the chromosome in bacteria or archaea?

05
Choose one
1 point

An assembly has several continuous sequences that need to be ordered and oriented, with estimated gaps allowed between them. Which assembly level describes that result?

  1. A

    A read

  2. B

    A contig

  3. C

    A scaffold

  4. D

    A chromosome

06
Choose all
1 point

Besides protein-coding genes, which kinds of regions may be present in a genome? Select all that apply.

  1. A

    Genes for functional RNAs

  2. B

    Regulatory sequences

  3. C

    Repetitive DNA

  4. D

    Only regions with fully established biological functions

  5. E

    Regions whose functions are uncertain or still under study

07
True or false
1 point

True or false: If a DNA region is conserved across species, that conservation proves the region has a particular function.

  1. A

    True

  2. B

    False

08
Written response
1 point

What term describes conserved gene order and neighborhood across genomes?

09
Fill in the blank
1 point

Homologous genes that diverged through speciation are , while homologous genes that arose through gene duplication are .

10
Choose one
1 point

A predicted gene model is supported by RNA-sequencing data and similarity to known proteins. Which interpretation of these evidence sources is most appropriate?

  1. A

    RNA-sequencing evidence alone proves the protein’s function.

  2. B

    RNA evidence may support an expressed transcript, and protein similarity may help identify a coding region or infer function.

  3. C

    Protein similarity directly establishes when and where a gene is expressed.

  4. D

    A predicted gene model is a direct guarantee of biological function.

11
Written response
1 point

An assembly consists of four sequences with lengths 8 kb, 5 kb, 4 kb, and 3 kb. What is its N50? Enter the value in kilobases.

12
Choose all
1 point

Which measures or evidence can complement N50 when assessing genome assembly quality? Select all that apply.

  1. A

    Total assembly length

  2. B

    Number of gaps

  3. C

    Read coverage

  4. D

    Recovery of expected genes

  5. E

    Consistency with independent biological evidence

13
Choose one
1 point

An analyst is comparing genomic coordinates reported from two releases of the same organism’s assembly. Which caution is most important?

  1. A

    Coordinates are guaranteed to remain unchanged across assembly versions.

  2. B

    An assembly version matters only when the organism changes.

  3. C

    Coordinates from different assembly versions may not match directly.

  4. D

    Annotations never change after their first release.

14
Open ended
1 point

A researcher wants to compare two DNA sequences, but is unsure whether their similarity extends across their full lengths or only within one region. Explain how local and global alignment differ, when each would be useful, and how insertions or deletions are represented.

15
Choose one
1 point

In a plant cell, where should researchers expect to find genomic DNA?

  1. A

    Only in nuclear chromosomes

  2. B

    In nuclear chromosomes, mitochondria, and chloroplasts

  3. C

    Only in mitochondria and chloroplasts

  4. D

    In nuclear chromosomes and plasmids

16
True or false
1 point

A species with a larger genome should be biologically more complex than a species with a smaller genome.

  1. A

    True

  2. B

    False

17
Choose one
1 point

An assembly links several contigs in an inferred order and orientation, but estimated gaps remain between them. What is this assembly structure called?

  1. A

    A single sequencing observation of part of a genome

  2. B

    A continuous assembled sequence with no gaps

  3. C

    An arrangement that orders and orients contigs, potentially with estimated gaps

  4. D

    A set of sequences assigned to chromosomes with all gaps resolved

18
Choose one
1 point

A researcher marks the boundaries of genes, transcripts, exons, and coding sequences on an assembled genome without assigning their biological roles. Which task is this?

  1. A

    Structural annotation

  2. B

    Functional annotation

  3. C

    Sequence alignment

  4. D

    Synteny analysis

19
Choose one
1 point

An assembly is fragmented where repetitive DNA makes short reads difficult to place. Why might adding long reads help?

  1. A

    They guarantee that every assembled sequence is correct and complete.

  2. B

    They eliminate the need to assess assembly quality.

  3. C

    They are used only to assign biological functions to genes.

  4. D

    They can span repeats and help connect distant regions.

20
Written response
1 point

What term describes homologous genes that diverged from one another through speciation?