01
Front
What is the main difference between antiplatelet drugs and anticoagulants?
Back
Antiplatelet drugs act mainly on platelet activation or aggregation; anticoagulants act mainly on coagulation factors and fibrin formation.
Free Online Flashcard Deck
1 Anticoagulation and Antiplatelet Therapy Principles Free Online FlashCards
Study 1 Anticoagulation and Antiplatelet Therapy Principles with 12 free online flashcards. Review key terms, definitions, and concepts with this interactive flashcard deck.
12 cards
02
Front
What is the final common pathway of coagulation?
Back
Factor Xa supports thrombin generation, and thrombin converts fibrinogen to fibrin, which stabilizes the clot.
03
Front
How does heparin reduce coagulation?
Back
Heparin enhances antithrombin activity, inhibiting thrombin and factor Xa; the relative effects depend on the heparin preparation.
04
Front
How does warfarin affect clotting-factor production?
Back
Warfarin inhibits vitamin K recycling, reducing production of functional factors II, VII, IX, and X, as well as proteins C and S.
05
Front
Which coagulation targets do the listed DOACs inhibit?
Back
Dabigatran directly inhibits thrombin; apixaban, edoxaban, and rivaroxaban directly inhibit factor Xa.
06
Front
How does aspirin inhibit platelet activity?
Back
Aspirin inhibits platelet cyclooxygenase, reducing thromboxane A₂ production and platelet activation.
07
Front
How does clopidogrel reduce platelet activation?
Back
Clopidogrel is a P2Y12 inhibitor that reduces ADP-mediated platelet activation.
08
Front
Which tests commonly guide IV unfractionated-heparin adjustment?
Back
Unfractionated heparin is commonly assessed using aPTT or a heparin-calibrated anti-Xa assay, according to the local protocol.
09
Front
Which test guides routine warfarin dosing?
Back
Warfarin dosing is adjusted using the INR, which standardizes the prothrombin-time result.
10
Front
How are DOACs usually monitored in routine care?
Back
DOACs usually do not require routine INR-based dose adjustment, but clinical follow-up—including kidney-function assessment when appropriate—remains important.
11
Front
What reversal agent is used for unfractionated heparin?
Back
Protamine sulfate is used to reverse unfractionated heparin.
12
Front
What approach may reverse warfarin in serious bleeding?
Back
When urgent reversal is indicated, warfarin may be reversed with vitamin K plus four-factor prothrombin complex concentrate (PCC).
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