01
True or false
1 point
True or false: A patient taking rivaroxaban for atrial fibrillation should take the dose with the evening meal.
Free Practice Quiz Question List
4 Direct Oral Anticoagulants Online Quiz Questions
Use this free practice quiz with 20 questions to review 4 Direct Oral Anticoagulants, test your knowledge, and prepare for your next test or exam.
20 questions
02
Fill in the blank
1 point
To avoid increasing drug exposure, dabigatran capsules must be swallowed .
03
Choose one
1 point
Which statement about postoperative use of direct oral anticoagulants is supported?
- A
They are used to prevent postoperative arterial strokes in every patient after surgery.
- B
Some may be used to prevent postoperative venous clots, depending on the drug and patient.
- C
They are used only after a postoperative clot has already caused symptoms.
- D
Every DOAC is appropriate for every postoperative patient.
04
Choose one
1 point
A patient with nonvalvular atrial fibrillation needs anticoagulation to reduce stroke risk. Which group of drugs may be considered, depending on patient factors?
- A
Aspirin, warfarin, and dabigatran only
- B
Apixaban, rivaroxaban, edoxaban, or dabigatran
- C
Apixaban and edoxaban only
- D
Any DOAC, including for every patient with a mechanical heart valve
05
Choose all
1 point
Select all the direct oral anticoagulants in this list that are factor Xa inhibitors.
- A
Apixaban
- B
Rivaroxaban
- C
Edoxaban
- D
Dabigatran
06
Written response
1 point
For apixaban dose reduction in nonvalvular atrial fibrillation, the age criterion is age 80 years or older. What is the threshold age, in years?
07
Choose one
1 point
A clinician is selecting an initial treatment regimen for acute DVT or PE. Which statement correctly distinguishes the DOAC options?
- A
Every DOAC requires at least five days of injectable anticoagulation first.
- B
Apixaban and rivaroxaban have initial oral treatment regimens, while dabigatran and edoxaban generally start after parenteral anticoagulation.
- C
Dabigatran is started only after the INR reaches 2.0.
- D
Edoxaban must be given with warfarin.
08
True or false
1 point
True or false: A standard PT/INR or aPTT result reliably quantifies the anticoagulant effect for any patient taking a DOAC.
- A
True
- B
False
09
Choose all
1 point
A stable patient takes a DOAC. Select all components of an appropriate periodic follow-up review.
- A
Review adherence.
- B
Ask about bleeding or clotting symptoms.
- C
Review current medications.
- D
Assess CBC.
- E
Assess kidney function.
- F
Assess liver function.
- G
Use routine INR testing to titrate the DOAC dose.
- H
Skip follow-up and laboratory assessment if the patient feels well.
10
Fill in the blank
1 point
For life-threatening bleeding in a patient taking dabigatran, its specific reversal agent is .
11
Choose one
1 point
A patient taking a DOAC is prescribed a strong P-glycoprotein or CYP3A4 inhibitor or inducer. What is the best general response?
- A
Assume the combination is harmless because DOACs have no interactions.
- B
Review the specific interacting drug, the DOAC, and kidney function.
- C
Use the INR to calculate a safe DOAC dose.
- D
Automatically double the DOAC dose if an inducer is prescribed.
12
Written response
1 point
In what month and year did U.S. commercial sales of andexanet alfa end? Enter the month and year in YYYY-MM format.
13
Choose one
1 point
Which statement best describes factor Xa inhibitor reversal in the United States as of 2026?
- A
Andexanet alfa remains routinely commercially available in the United States.
- B
Andexanet alfa was previously approved for apixaban- or rivaroxaban-associated life-threatening or uncontrolled bleeding, but U.S. commercial sales ended in December 2025; 4F-PCC may be considered under local emergency protocols.
- C
Idarucizumab reverses all four DOACs.
- D
Vitamin K reliably reverses apixaban, rivaroxaban, and edoxaban.
14
Open ended
1 point
A colleague suggests substituting one DOAC for another without reassessing the patient. Explain why this is not a safe general assumption, and identify at least three drug or patient factors that should inform selection.
15
Choose one
1 point
For a patient with nonvalvular atrial fibrillation who needs anticoagulation to reduce stroke risk, which group consists of DOACs that may be considered, depending on patient factors?
- A
Apixaban, rivaroxaban, edoxaban, or dabigatran
- B
Aspirin only
- C
A DOAC for every patient with a mechanical heart valve
- D
A DOAC only for acute pulmonary embolism
16
True or false
1 point
A patient taking dabigatran should swallow the capsules whole rather than opening or chewing them.
- A
True
- B
False
17
Choose one
1 point
A patient taking apixaban for nonvalvular atrial fibrillation meets only one of these criteria: age at least 80 years, body weight at most 60 kg, or serum creatinine at least 1.5 mg/dL. Which statement best describes the labeled dose-reduction rule?
- A
Reduce the dose if any one criterion is present.
- B
Reduce the dose if at least two criteria are present.
- C
Reduce the dose for everyone older than 65 years.
- D
Use the INR to determine the dose.
18
Choose one
1 point
A patient with nonvalvular atrial fibrillation asks when to take a once-daily rivaroxaban dose. Which counseling point is correct?
- A
Take the atrial-fibrillation dose with the evening meal.
- B
Open dabigatran capsules and sprinkle their contents on food.
- C
Take every DOAC with food.
- D
Take rivaroxaban for atrial fibrillation on an empty stomach.
19
Written response
1 point
A patient taking dabigatran develops life-threatening bleeding. What is the specific reversal agent?
20
Written response
1 point
In what month and year did U.S. commercial sales of andexanet alfa end?
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