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Free Practice Quiz Question List

4 Transplantation and Immune Compatibility Online Quiz Questions

Use this free practice quiz with 20 questions to review 4 Transplantation and Immune Compatibility, test your knowledge, and prepare for your next test or exam.

20 questions
01
True or false
1 point

True or false: Vaccination needs should be reviewed before transplantation because substantial immunosuppression can affect vaccine effectiveness or suitability.

  1. A

    True

  2. B

    False

02
Choose one
1 point

In graft-versus-host disease after an allogeneic hematopoietic cell transplant, which cells directly drive the characteristic attack on the recipient?

  1. A

    The recipient's immune system attacks the donor graft.

  2. B

    Donor T cells attack the recipient's tissues.

  3. C

    Donor antibodies attack the donor's tissues.

  4. D

    The recipient's T cells attack the recipient's tissues.

03
Fill in the blank
1 point

A transplant team tests whether a candidate's serum reacts with cells from a proposed donor. What is this test called?

04
Written response
1 point

What compatibility assessment compares a recipient's known antibody profile with a proposed donor's HLA type?

05
Choose one
1 point

A patient is receiving stronger immunosuppressive treatment around the time of transplantation to reduce early rejection risk. Which phase of the regimen is this?

  1. A

    Ongoing combination therapy used after the initial transplant period.

  2. B

    Stronger treatment around the time of transplant to reduce early rejection risk.

  3. C

    A test that determines whether recipient serum reacts with donor cells.

  4. D

    A treatment phase used only after chronic rejection develops.

06
True or false
1 point

True or false: A positive crossmatch can indicate high risk of antibody-mediated injury to a proposed graft.

  1. A

    True

  2. B

    False

07
Fill in the blank
1 point

Complete each statement with the immune system's origin. In solid-organ rejection, the immune system attacks the graft. In GVHD, immune cells from the attack the recipient's tissues.

08
Choose all
1 point

A transplant candidate has pre-existing antibodies against donor HLA. Select all experiences identified as possible sources of such antibodies.

  1. A

    Pregnancy

  2. B

    Taking prescribed corticosteroids

  3. C

    Blood transfusion

  4. D

    A prior transplant

09
Choose one
1 point

A kidney transplant recipient has a new change in graft function. What is the most appropriate interpretation?

  1. A

    It confirms acute rejection, so no further assessment is needed.

  2. B

    It proves that immunosuppressant levels are too low.

  3. C

    It may have several causes, so transplant-specific evaluation may be needed.

  4. D

    It establishes chronic rejection if the recipient has no fever.

10
Written response
1 point

Which type of rejection develops over time and involves persistent immune injury and scarring?

11
Choose all
1 point

Which actions are appropriate parts of post-transplant care? Select all that apply.

  1. A

    Monitor graft function and medication effects.

  2. B

    Report new medicines, missed doses, or side effects to the transplant team.

  3. C

    Stop immunosuppressants when feeling well to reduce medication risks.

  4. D

    Follow an individualized plan for infection prevention and follow-up.

12
Choose one
1 point

Why might a solid-organ transplant regimen combine medicines that act at different points in the immune response?

  1. A

    The combination guarantees that rejection and infection will not occur.

  2. B

    Different drugs can act at different points in the immune response, though immunosuppression still has risks.

  3. C

    Using several drugs eliminates the need to monitor medication effects.

  4. D

    Combination therapy is used because every drug has the same mechanism and adverse effects.

13
Open ended
1 point

A kidney candidate has antibodies against an HLA antigen carried by a proposed donor, and a crossmatch is positive. Explain what this result may mean and how the transplant team can assess compatibility risk. Include why a compatibility assessment cannot guarantee that rejection will not occur.

14
Choose one
1 point

A kidney transplant recipient takes a calcineurin inhibitor such as tacrolimus. Which medication-related concern makes monitoring important?

  1. A

    They can cause kidney toxicity.

  2. B

    They eliminate the risk of infection.

  3. C

    They prevent all antibody formation.

  4. D

    They are used only for GVHD prevention.

15
Choose one
1 point

Which situation describes the defining immune direction and transplant context of graft-versus-host disease?

  1. A

    Recipient B cells attacking donor blood vessels in solid-organ rejection.

  2. B

    Medication toxicity reducing graft function after any transplant.

  3. C

    Immunocompetent donor T cells recognizing recipient tissues as foreign after an allogeneic hematopoietic cell transplant.

  4. D

    Recipient T cells recognizing donor cells in solid-organ rejection.

16
Choose one
1 point

A transplant program gives a patient stronger immunosuppressive treatment around the time of transplantation, followed by ongoing combination therapy. What is the main purpose of the stronger initial phase?

  1. A

    To treat infections identified before transplantation

  2. B

    To reduce early rejection risk with stronger treatment around the time of transplantation

  3. C

    To replace all ongoing immunosuppressive medicines after the first week

  4. D

    To prevent every possible cause of graft dysfunction

17
True or false
1 point

A negative crossmatch guarantees that a transplant recipient will not develop rejection.

  1. A

    True

  2. B

    False

18
Choose one
1 point

A transplant recipient develops a change in graft function. Which interpretation is most appropriate?

  1. A

    It establishes rejection, so no further evaluation is needed

  2. B

    It establishes medication toxicity unless the patient has a fever

  3. C

    It may have several causes, so the transplant team determines what evaluation is needed

  4. D

    It can only be caused by obstruction or recurrence of the original disease

19
Written response
1 point

In a common kidney-transplant maintenance regimen, which antimetabolite is often combined with a calcineurin inhibitor and corticosteroids?

20
Written response
1 point

What term describes antibodies in a recipient that recognize the proposed donor's HLA?