What is the term for TB infection that is not active TB disease?
6 Integrated Clinical Cases and Review Online Quiz Questions
Use this free practice quiz with 20 questions to review 6 Integrated Clinical Cases and Review, test your knowledge, and prepare for your next test or exam.
True or false: Lupus nephritis can result from autoimmune injury to the body's own kidney tissues.
- A
True
- B
False
True or false: A transplant recipient taking immunosuppressive medication can safely wait several days to seek advice about a new fever if the symptoms seem mild.
- A
True
- B
False
In transplant care, immunosuppression helps prevent but increases susceptibility to .
In severe immunosuppression, a live vaccine may be unsafe because its weakened organism could still .
A patient taking strong immunosuppressive medication is offered a live-attenuated vaccine. What should be checked before vaccination?
- A
Whether the vaccine will cause a reduced immune response
- B
Whether the live vaccine is safe for the person's degree of immunosuppression and treatment
- C
Whether the patient has had a transplant within the past four months
- D
Whether the vaccine can prevent autoimmune disease
A kidney-transplant recipient misses several doses of tacrolimus and then notices reduced urine output. What serious transplant complication must be considered?
A patient with lupus nephritis taking prednisone and mycophenolate develops fever and a new cough. Why should infection be assessed promptly rather than assuming the symptoms are a lupus flare?
- A
Because immunosuppressive treatment can increase infection risk, so infection needs prompt assessment before assuming a flare
- B
Because fever and cough are sufficient evidence that lupus is damaging the kidneys
- C
Because mycophenolate prevents infections but prednisone causes them
- D
Because immunosuppressive treatment removes the possibility of a lupus flare
Which factors can influence infection risk in a transplant recipient? Select all that apply.
- A
Time since transplant
- B
Whether the patient's symptoms seem mild
- C
Intensity of immunosuppressive treatment
- D
Whether the patient has a fever
- E
The patient's clinical circumstances
A patient with rheumatoid arthritis recalls a previous positive TB test but is unsure whether they were treated. They are preparing to start a TNF inhibitor. Explain what the care team should establish before therapy and why the medication makes this important.
Before a patient with a previous positive TB test starts a TNF inhibitor, which statements should guide the care team's approach? Select all that apply.
- A
Clarify the TB history and evaluate for TB infection or disease before proceeding
- B
Treat a positive TB test as proof of active disease without further evaluation
- C
Recognize that TNF inhibition can increase the risk of TB progressing to active disease
- D
Assume that uncertainty about prior treatment means the patient has no TB-related risk
A kidney-transplant recipient misses several tacrolimus doses and notices reduced urine output, but has no fever. What is the safest response?
- A
Assume the reduced urine output proves rejection and increase tacrolimus without advice
- B
Consider rejection and contact the transplant team promptly for assessment
- C
Wait for fever before contacting the transplant team
- D
Stop immunosuppressive medication until urine output returns to normal
For a patient taking immunosuppressive medication, what is often the principal concern with a non-live vaccine?
- A
The vaccine's weakened organism may cause harm
- B
The immune response may be reduced
- C
The vaccine necessarily causes active TB
- D
The vaccine increases the risk of transplant rejection
Lupus nephritis involves immune activity that can injure the body’s own tissues, including the kidneys.
- A
True
- B
False
Which statement best describes the trade-off of immunosuppressive treatment after a solid-organ transplant?
- A
It reduces rejection risk and also lowers susceptibility to infection.
- B
It reduces rejection risk but increases susceptibility to infection.
- C
It increases rejection risk but lowers susceptibility to infection.
- D
It increases both rejection risk and susceptibility to infection.
A patient has persistently low immunoglobulin levels, repeated bacterial sinus and lung infections, and several Giardia infections. Which immune function is most likely impaired?
A patient taking strong immunosuppressive medication is offered a live-attenuated vaccine. Which statement best describes the general safety distinction between live and non-live vaccines?
- A
Live vaccines are generally preferred in severe immunosuppression because they create a stronger response.
- B
Live and non-live vaccines have the same main safety concern in severe immunosuppression.
- C
Live vaccines may be unsafe in severe immunosuppression, while non-live vaccines may produce a reduced immune response.
- D
Non-live vaccines are generally avoided because they contain a weakened organism that can cause infection.
A patient with lupus nephritis taking prednisone and mycophenolate develops fever and a new cough. What is the most appropriate general response?
- A
Assume the fever and cough are a lupus flare and increase immunosuppression immediately.
- B
Assess promptly for infection instead of assuming the symptoms are a lupus flare.
- C
Wait to assess for infection unless the patient develops a rash.
- D
Stop both medicines without consulting the prescribing team.
What is the name for TB infection without active TB disease, which may be considered for treatment after active disease has been excluded?
A patient with rheumatoid arthritis reports a previous positive TB test but is unsure whether they were treated. Before starting a TNF inhibitor, what should the care team do?
- A
Start the TNF inhibitor because a past positive TB test indicates protection from active TB.
- B
Repeat the TB test and start therapy if the result is still positive, without further evaluation.
- C
Clarify the TB history and arrange clinical evaluation before proceeding because the medication can increase the risk of progression to active TB.
- D
Begin treatment for latent TB immediately, without first assessing for active disease.
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