01
Front
What effects do leukotrienes have on the airways?
Back
They contribute to airway inflammation, bronchoconstriction, mucus production, and airway swelling.
Free Online Flashcard Deck
4 Leukotriene Modifiers and Mucolytics Free Online FlashCards
Study 4 Leukotriene Modifiers and Mucolytics with 12 free online flashcards. Review key terms, definitions, and concepts with this interactive flashcard deck.
12 cards
02
Front
Are leukotriene modifiers rescue treatments for acute asthma?
Back
They are used for ongoing control or prevention, not to relieve an acute asthma attack.
03
Front
How do montelukast and zafirlukast work?
Back
Montelukast and zafirlukast block cysteinyl-leukotriene (CysLT₁) receptors.
04
Front
How does zileuton reduce leukotriene production?
Back
Zileuton inhibits 5-lipoxygenase, reducing leukotriene synthesis.
05
Front
What serious risk is highlighted by montelukast’s boxed warning?
Back
Montelukast carries a boxed warning for serious neuropsychiatric events. New symptoms should be reported promptly to a health professional.
06
Front
When is montelukast generally considered for allergic rhinitis?
Back
It is generally reserved for patients who do not respond to or cannot tolerate alternatives.
07
Front
What important organ toxicity is associated with zafirlukast?
Back
Zafirlukast can cause liver injury; monitor for signs of hepatic problems.
08
Front
What is an important zafirlukast–warfarin concern?
Back
Zafirlukast can increase prothrombin time with warfarin, so appropriate monitoring is needed.
09
Front
What liver-related risk is associated with zileuton?
Back
Zileuton can cause liver injury.
10
Front
Which drug levels can zileuton raise?
Back
Zileuton can raise theophylline and warfarin levels; monitoring and dose adjustment may be needed.
11
Front
How does inhaled acetylcysteine thin mucus?
Back
Acetylcysteine disrupts disulfide bonds in mucus proteins, reducing mucus viscosity.
12
Front
What should be done if bronchospasm worsens during inhaled acetylcysteine treatment?
Back
It can provoke bronchospasm. Monitor the patient and discontinue it if bronchospasm progresses.
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